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Brand name: quinine
Generic name: Quinarsal, Qualaquin, Apo-Quinine, Novo-Quinine, Quinine-Odan, Aethylcarbonis Chinin, Circonyl, Genin, Kinin, Q200, Q300, Quinate, Quinbisu, Quinimax, Quininga, Quinsul
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Quinine was used starting in the 17th century as a prophylactic against malaria. Quinine is approved for treatment of malaria, but is also commonly prescribed to treat leg cramps and similar conditions. Quinine drugs are associated with serious side effects, such as cardiac arrhythmias, thrombocytopenia (a decrease in blood platelets that can cause hemorrhage or clotting problems), and severe hypersensitivity reactions. The development of more effective alternatives such as quinacrine, chloroquine, and primaquine in the twentieth century reduced the reliance on quinine. Unlike the approved product, many unapproved quinine drug products are marketed without labeling cautioning against use of the product for treatment of leg cramps.

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