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In a long-term, randomized, placebo-controlled study of Type 2 diabetic patients unresponsive to dietary management, Amaryl therapy improved postprandial insulin/C-peptide responses, and 75% of patients achieved and maintained control of blood glucose and HbA1c. The reductions in mean area under the prothrombin time (PT) curve and maximum PT values during Amaryl treatment were very small (3. Should secondary failure occur with combined Amaryl/metformin therapy, it may be necessary to initiate insulin therapy. On the basis of results from animal studies, Amaryl (glimepiride tablets) should not be used during pregnancy. In addition, Amaryl 1-mg tablets contain Ferric Oxide Red, Amaryl 2-mg tablets contain Ferric Oxide Yellow and FD&C Blue #2 Aluminum Lake, and Amaryl 4-mg tablets contain FD&C Blue #2 Aluminum Lake.

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