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Brand name: aciphex
Generic name: Rabeprazole, Pariet, Rablet
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The median inhibitory effect of Aciphex on 24 hour gastric acidity is 88% of maximal after the first dose. For those patients who have not healed after 8 weeks of treatment, an additional 8-week course of Aciphex may be considered. In healthy male volunteers treated with Aciphex for 13 days, no clinically relevant changes have been detected in the following endocrine parameters examined: 17 β-estradiol, thyroid stimulating hormone, tri-iodothyronine, thyroxine, thyroxine-binding protein, parathyroid hormone, insulin, glucagon, renin, aldosterone, follicle-stimulating hormone, luteotrophic hormone, prolactin, somatotrophic hormone, dehydroepiandrosterone, cortisol-binding globulin, and urinary 6β-hydroxycortisol, serum testosterone and circadian cortisol profile. Aciphex was significantly superior to placebo in producing healing of duodenal ulcers. The name and strength, in mg, (Aciphex 20) is imprinted on one side. , randomized, double-blind, multicenter study assessing the effectiveness of 20 mg and 40 mg of Aciphex QD versus placebo for healing endoscopically defined duodenal ulcers, 100 patients were treated for up to four weeks.
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